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Contraindicated (1)phenobarbital will lower the level or result of naloxegol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Use of naloxegol with solid CYP3A4 inducers is just not suggested(16 calendar year outdated Lady developed fever, facial edema, lymphadenopathy and rash 3 weeks right after beginning phenobarbital a